Benzoyl peroxide is a popular over-the-counter treatment for acne and rosacea, but it is not safe for everyone due to risks of severe allergic reactions, skin irritation, and other issues.[1][2][6]
People with a history of hypersensitivity to benzoyl peroxide or similar products can experience serious reactions like anaphylaxis, angioedema, swelling of the face, lips, tongue, eyes, or trouble breathing.[1][6] These life-threatening allergies have prompted FDA warnings for over-the-counter acne products containing it.[6] If such symptoms appear, users must stop the product right away and seek medical help.[1]
Even without allergies, many face skin problems such as redness, dryness, peeling, burning, stinging, itching, or contact dermatitis.[1][2] These effects are common at the start of treatment and can worsen on sensitive skin, cuts, abrasions, sunburned areas, or eczematous skin.[1][2] Applying moisturizer may help mild cases, but severe irritation often requires stopping use and consulting a doctor.[1][2]
Those with very sensitive skin or existing conditions should avoid it, as it can make problems worse.[2] Combining benzoyl peroxide with other topical acne treatments or certain antibiotics raises the risk of extra dryness and irritation.[4][5] Overuse leads to more peeling, swelling, or damage without faster results.[2]
Pregnant or breastfeeding individuals need caution, though studies suggest low systemic absorption and no direct fetal harm from topical use.[1] Still, doctors advise checking before starting.[2]
Sources
https://prescriberpoint.com/therapies/epsolay-507e2cd
https://pharmeasy.in/molecules/clindamycin-benzoyl-peroxide-1451
https://pmc.ncbi.nlm.nih.gov/articles/PMC12691598/
https://www.doctronic.ai/blog/4-benzac-interactions-what-to-avoid-when-youre-taking-benzac/
https://www.doctronic.ai/blog/5-benzoyl-peroxide-interactions-what-to-avoid-when-youre-taking-benzoyl-peroxide/
https://www.consultant360.com/exclusives/fda-warns-life-threatening-allergic-reactions-otc-acne-products
https://www.henryschein.co.nz/documents/msds/LIVE/Vertex/Vertex%20Orthoplast%20Pwd,%20Holland%20Dental%20Orthoplast%20Pwd_SDS_Exp_20261116.pdf
